Evidence-based medicine has generated many philosophical and pragmatic challenges to clinical care. Chief among these challenges is how to deliver culturally appropriate individualized endocrine care while adhering to evidence-based guidelines and algorithms developed for large heterogeneous populations.

Since its inception, the American Association of Clinical Endocrinologists (AACE) has advocated for the finest in endocrine education and state-of-the-art health-care delivery without regard to race, ethnicity, gender, age, country of origin, economic status, lifestyle, sexual orientation or domestic living arrangements.

Several recent publications have raised concern that testosterone therapy in men increases cardiovascular risks. Media reports declared that testosterone therapy is dangerous, without addressing the scientific validity of these studies.

The most recent American Association of Clinical Endocrinologists (AACE)/American College of Endocrinology (ACE) clinical practice guidelines for the treatment of menopause was published in 2011 (1).

Off-label use and misuse of testosterone, GH, thyroid hormone, and adrenal supplements have become increasingly prevalent.